Dr. Manouchehr Hessabi
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2014 to present

Stroke Outcomes Research

Data management and analytic support for multi-center acute ischemic stroke trials, including the landmark SELECT2 trial of endovascular thrombectomy for large ischemic strokes, with primary publications in NEJM, The Lancet, and JAMA Neurology.

Location

United States and international collaborators

Indexed papers

4

About the program

This line of work applies rigorous data-management and biostatistical methods to multi-center stroke registries and randomized trials, contributing to the evidence base that shapes how acute ischemic stroke is treated around the world. As Data Manager on the SELECT2 trial, Dr. Hessabi supported the REDCap infrastructure behind the primary NEJM publication and its Lancet and JAMA Neurology follow-ups. Earlier work contributed to the ARTSS, ARTSS-2, CLOTBUST-HF, and PETREVASC trials.

Key findings

  1. 01

    Endovascular thrombectomy benefits large-ischemic-stroke patients across a wider range of imaging profiles than previously established (SELECT2, NEJM 2023).

  2. 02

    One-year outcomes from SELECT2 reinforce the durability of the thrombectomy effect in large-core strokes (Lancet 2024).

  3. 03

    Outcomes differ meaningfully between direct-presenting and transferred patients, with implications for stroke-network design (JAMA Neurology 2024).

  4. 04

    Younger stroke onset in low- and middle-income countries tracks measurably with access to and quality of healthcare.

Collaborators

  • Dr. Amrou Sarraj (UTHealth / University Hospitals Cleveland)
  • Dr. Andrew Barreto (UTHealth)
  • Dr. Mohammad H. Rahbar (UTHealth)
  • The SELECT2 Investigators

Publications in this program

  1. 2024JAMA Neurology22 citations

    Endovascular thrombectomy treatment effect in direct vs transferred patients with large ischemic strokes: a prespecified analysis of the SELECT2 trial

    Sarraj A, Hill MD, Hussain MS, Abraham MG, Ortega-Gutierrez S, Chen M, et al.

  2. 2024The Lancet45 citations

    Endovascular thrombectomy plus medical care versus medical care alone for large ischaemic stroke: 1-year outcomes of the SELECT2 trial

    Sarraj A, Abraham MG, Hassan AE, Blackburn S, Kasner SE, Ortega-Gutierrez S, et al.

  3. 2023New England Journal of Medicine520 citations

    Trial of endovascular thrombectomy for large ischemic strokes

    Sarraj A, Hassan AE, Abraham MG, Ortega-Gutierrez S, Kasner SE, Hussain MS, et al.

  4. 2022Annals of Clinical and Translational Neurology82 citations

    Younger age of stroke in low-middle income countries is related to healthcare access and quality

    Rahbar MH, Medrano M, Diaz-Garelli F, Gonzalez Villaman C, Saroukhani S, Kim S, et al.